Harp 312/24/2023 ![]() ![]() Among those with predialysis renal failure or a functioning transplant at baseline, aspirin did not increase the number of patients who progressed to dialysis therapy (7 of 187 versus 6 of 188 patients P = NS) or experienced a greater than 20% increase in creatinine level (63 of 187 patients versus 56 of 188 patients P = NS). Allocation to treatment with 100 mg of aspirin daily was not associated with an excess of major bleeds (aspirin, 4 of 225 patients versus placebo, 6 of 223 patients P = not significant ), although there was a 3-fold excess of minor bleeds (34 of 225 versus 12 of 223 patients P = 0.001). ![]() Compliance with study treatments was 80% at 12 months. Overall, 448 patients with chronic kidney disease were randomly assigned (242 predialysis patients with a creatinine level > or = 1.7 mg/dL, 73 patients on dialysis therapy, and 133 patients with a functioning transplant). Patients were randomly assigned in a 2 x 2 factorial design to the administration of: (1) 20 mg of simvastatin daily versus matching placebo, and (2) 100 mg of modified-release aspirin daily versus matching placebo. Patients with chronic kidney disease are at increased risk for cardiovascular disease, but the efficacy and safety of simvastatin and aspirin are unknown in this patient group. ![]()
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